Caralluma fimbriata is an edible cactus that grows in Africa the Middle East Asia and India. It has been traditionally used for centuries by Indigenous hunters to suppress hunger and appetite and improve stamina. The best available evidence still suggests that a healthy lifestyle which includes reduced calorie intake and increased physical activity levels is our best weapon for losing fat keeping it off. Caralluma fimbriata may play a role in facilitating this process. The studies that have been conducted utilizing n extract from this cactus show promise.How does it workUnderstanding the appetite control mechanisms: A region of the brain known as the Hypothalamus and at its base the Pituitary gland is central to the appetite control mechanism. It has been established that appetite is modulating by several different hormonal pathways that control either orexigenic (appetite stimulation) or anorexogenic (appetite suppression).The chart below shws ome of the different polypeptides (neuropeptides) produced by the body and identified by researchers that influence the regulation of appetite.Orexigenic Neuropeptides (Appetite Stimulating)- Agouti-related protein (AgRP)- Gherelin- Neuropeptide Y (NPY)- Fibroblast Groth Factor 19 (FGF 19)Anorexigenic Neuropeptides (Appetite suppressing)- Leptin (produced in fat cells)- Cholecystokinin (CCK)- Incretins- Peptides YYA review of the scientific literature reveals that the genus Caralluma contains many glycosidic (flavones glycosides flavones magastigmane glycosides) compounds. In Caralluma extract (CE) researches have identified a particular form - Pregnance glycosides as one of the major constituents. In studies from other plant species Pregnance glycosides appear to modulate food intake (suppress appetite) by decreasing the activity of one or more of the orexigenic neuropeptides (See the chart above).About Irvingia Gabonensis :Irvingia Gabonensis (African Mango) is a tree that growa in the Eastern Central African states. A